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Please click here for the Lenzetto® Prescribing Information.

COMPARING TRANSDERMAL THERAPIES

Comparing transdermal HRT therapies
when starting patients on HRT

Lenzetto®
(spray)
Gel Patch
Avoids first-pass liver metabolism
Yes1 Yes1 Yes1
Dosing and administration
1, 2 or 3 metered-dose sprays of Lenzetto® (each containing 1.53 mg of estradiol) applied to inner forearm daily2 Oestrogel® 750 μg estradiol​/​actuation gel: Pump-pack actuation. Two pumps (2.5g) of Oestrogel® once daily (1.5 mg estradiol) is the usual starting dose3

Sandrena® 1mg estradiol gel: Gel sachet. The usual starting dose is 1.0 mg estradiol (1.0 g gel) daily but the selection of the initial dose can be based on the severity of the patient’s symptoms. Dose can be readjusted after 2-3 cycles individually from 0.5 g to 1.5 g per day4
Evorel Sequi® 50 mcg estradiol/ day patch: adhesive patch delivering 25, 50, 75 and 100 mcg of estradiol over 24 hours5
Drug half-life
Estradiol values did not return to baseline by 168 hours after the last dose7 Oestrogel® 750 μg estradiol​/​actuation gel: 36 hours8
Sandrena® 1 mg estradiol gel: half-life not available9
Evorel Sequi® 50 mcg estradiol/day patch: 6.6 hours5
Application site adverse events
Skin irritation for Lenzetto®: uncommon (≥1/1,000 to <1/100).2
Treatment-related application site reaction rate was similar to placebo10
Skin reactions for Oestrogel® and Sandrena®: range from common (≥1/100 to <1/10) to uncommon (≥1/1,000 to <1/100)3,4 Evorel Sequi® local skin reactions (including pruritis and rash): common5

Avoid first-pass liver metabolism:1

Lenzetto®:2

Oestrogel®:3

Sandrena®:4

Evorel Sequi®:5

Estradot®:6

Lenzetto®:7

Oestrogel®:3

Sandrena®:9

Evorel Sequi®:5

Lenzetto®:10

Evorel Sequi®:5

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NEW 20% MDS REBATE FOR DISPENSING DOCTORS
Gedeon Richter are offering a NEW 20% MDS rebate on Lenzetto® for dispensing doctors, when ordering via PSUK.
Use PIP codes:
414-9092 to order a single pack of Lenzetto®
414-9100 for a multi-pack (three units)