LENZETTO®: INITIATION AND FLEXIBLE DOSING
Defined starting dose1
Start with 1 spray (90 μL = 1.53 mg estradiol) once daily1*
Flexible dosing1
Adjust according to symptom control – increase by 1 spray after 4 weeks if needed, up to a maximum of 3 sprays per day1
Provides relief from menopause symptoms3
Significant improvement in hot flushes can be seen from as early as 2 weeks, with maximum effect by 3 months3
![Arm]()
![Leg]()
Sprays should not overlap and be in the same position along the inner forearm or thigh each day1
![Device]()
Lenzetto® should be held in an upright position when sprayed to ensure full dose delivery1
In postmenopausal women with an intact uterus, combine Lenzetto® with a suitable dose of an approved progestogen1
*Taking a break between Lenzetto® and other HRT products is not necessary2
Support materials for patients
Patient treatment tracker
The Lenzetto carton features an integral tracker located on the side panel, to aid the simple tracking of their treatment.
It is very important that your patient retains the tracker until the last spray.1
![Lenzetto carton showing the treatment tracker on the side panel. Not actual pack. Illustration only.]()
Not actual pack.
Illustration only.How to use the tracker
Before a new applicator is used for the first time, the pump should be primed by spraying three times with the cover on.
- To track the priming sprays, your patient should mark each primed spray with an
"x" in the table.- To track the daily dose, your patient should mark each expelled spray with an
"x" in the table.Your patient should not use the Lenzetto device for more than 56 sprays, even if it is not completely empty.
-
Taking a break between Lenzetto® and other HRT products is not necessary2
-
One spray (90 μL) is the recommended starting dose of Lenzetto®1
-
It is possible that some symptoms may reappear whilst the patient is becoming established on a new treatment as HRT may take time to impact symptoms1
-
If after four weeks of continuous treatment with Lenzetto® symptoms persist, this may be because the dose is not high enough.1,4 The dose of Lenzetto® can be increased to two or three sprays1
-
When blood tests are being taken as part of menopause management, it might be advised that blood samples are not taken from the arm that Lenzetto® is being applied to, where estradiol levels will be higher
-
Lenzetto® should be held in the upright position when sprayed to ensure full dose delivery1
-
Lenzetto® should be sprayed in the same position(s) along the inner forearm each day1
-
Lenzetto® does not need to be rubbed in after being sprayed1
-
If sunscreen is applied to the Lenzetto® application site about one hour after spraying, estradiol absorption may be reduced by approximately 10%. Applying sunscreen before Lenzetto® has not been shown to affect absorption. This applies only to the specific area where Lenzetto® is sprayed1
-
The drug application area can be washed after one hour1
-
Patients should track their Lenzetto® doses each day using the tracker contained on the outside of the Lenzetto® box1
- When oestrogen is prescribed for a postmenopausal woman with a uterus, a progestagen approved for addition to oestrogen treatment should also be initiated for at least 12-14 of every 28-day cycle, to reduce the risk of endometrial cancer. Only progestogens approved for addition to oestrogen treatment should be administered1
- When oestrogen is prescribed for a postmenopausal woman who has had a hysterectomy, but has a previous diagnosis of endometriosis, consideration should be given to addition of a progestagen approved for addition to oestrogen to the treatment regimen1,5