EFFICACY AND MODE OF ACTION OF LENZETTO®

Lenzetto® Mode of action: Evaporative
delivery is an innovation in HRT^1–3

With it’s evaporative solution, Lenzetto®
achieves quick-drying transdermal delivery³

Lenzetto® is sprayed on the surface of the skin with an alcohol-based evaporative solution delivering the estradiol and penetration enhancer¹

The solution evaporates and the estradiol and enhancer absorb through the skin surface¹

The estradiol and enhancer form a reservoir under the skin, from where the estradiol is slowly absorbed to the circulation¹

Transdermal delivery bypasses first-pass hepatic metabolism, allowing administration of lower doses than oral HRT – putting Lenzetto® in line with the International Menopause Society guideline recommendations to titrate HRT to the lowest effective dose.^3,4

The unique* spray design and innovative delivery of Lenzetto® are shown in this mode of action video.^1,2

*Lenzetto® has not been determined as superior to other HRT formulation. Here, unique is used to describe the fact that Lenzetto® is currently the only HRT with a spray design.

†The primary efficacy endpoints were mean change from baseline in frequency and severity of moderate-to-severe hot flushes at weeks 4 and 12.

Lenzetto® reduces both the frequency and intensity of hot flushes vs placebo⁵

Adapted from Kovacs G, et al. Climacteric. 2016.

Lenzetto® was shown to have similar efficacy
to patches of similar doses when indirectly
compared in a network meta-analysis⁶

In a network meta-analysis of eight RCTs comparing the efficacy of Lenzetto® and patch HRT formulations relative to placebo (indirect comparison)⁶

• Lenzetto® was reported to be an effective relief for hot flushes compared with placebo⁶
• There was no significant difference between Lenzetto® and the patch at any dose⁶