EFFICACY AND MODE OF ACTION

Lenzetto® spray

Alcohol-based evaporative solution delivers estradiol and penetration enhancer to the skin¹

Absorption

Solution evaporates and the active ingredient penetrates the skin barrier¹

Reservoir formation

The estradiol and enhancer create a reservoir beneath the skin, providing a slow, consistent release into circulation¹

• Transdermal delivery bypasses first-pass hepatic metabolism, allowing administration of lower doses than oral HRT³
• Consistent with the International Menopause Society guideline recommendations to titrate HRT to the lowest effective dose⁴

The unique* spray design and innovative delivery of Lenzetto® are shown in this mode of action video.^1,2

*Lenzetto® has not been determined as superior to other HRT formulation. Here, unique is used to describe the fact that Lenzetto® is currently the only HRT with a spray design.

Weekly change from baseline in hot flush frequency rate over 12 weeks

Weekly change from baseline in hot flush severity score over 12 weeks

^†The primary efficacy endpoints were mean change from baseline in frequency and severity of moderate-to-severe hot flushes at weeks 4 and 12.

Lenzetto® reduces both the frequency and intensity of hot flushes vs placebo⁵

Adapted from Kovacs G, et al. Climacteric. 2016.

Lenzetto® was shown to have similar efficacy
to patches of similar doses when indirectly
compared in a network meta-analysis⁶

In a network meta-analysis of eight RCTs comparing the efficacy of Lenzetto® and patch HRT formulations relative to placebo (indirect comparison)⁶

• Lenzetto® was reported to be an effective relief for hot flushes compared with placebo⁶
• There was no significant difference between Lenzetto® and the patch at any dose⁶

Adapted from Kovacs G, et al. Climacteric. 2016.